Revisiting the complex architecture of ALS in Turkey: Expanding genotypes, shared phenotypes, molecular networks, and a public variant database

Tunca et al. (2020) used Genomize-SEQ to analyze whole-exome sequencing data from 1,200 Turkish ALS patients. They revealed that established ALS genes explain only 35% of familial cases, far fewer than in Western cohorts, highlighting the distinct genetic landscape of ALS in Turkey.